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KMID : 1007520150240041513
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Food Science and Biotechnology
2015 Volume.24 No. 4 p.1513 ~ p.1521
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Anti-adipogenic Effects in 3T3-L1 Cells of Acetone Extracts and Fractions from Styrax japonica Fruit
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Kim Jin-Kyu
Nam Ha-Jin
Kim Yoo-Yeon
Jung Ha-rry
Choi Yoon-Soo
Oh Joa-Sub
Chun Su-Kyoung
Suh Jun-Gyo
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Abstract
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Reduction in reactive oxygen species (ROS) production facilitated by Styrax japonica (SJ) extracts and fractions for inhibition of obesity development through inhibition of adipogenesis was investigated. Treatment of cells with SJ extracts and fractions did not result in changes in cell viability. SJ extracts and fractions inhibited lipid accumulation in a dose-dependent manner during adipogenesis. Expressions of PPARγ and C/EBPα, key adipogenic markers, were decreased in cells treated with SJ extracts and fractions. Inhibitory effects of SJ extracts and fractions were the most powerful in the early stages of differentiation (days 0-2). Intracellular ROS production was decreased in cells treated with SJ extracts and fractions. SJ extracts and fractions can inhibit adipogenesis via reduced ROS levels, which involves down-regulation of adipogenic transcription factors.
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KEYWORD
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adipogenesis, obesity, Styrax japonica, ROS
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